Crofab Crotalidae Polyvalent Immune Fab (ovine)

-----------------DOSAGE AND ADMINISTRATION---------------For intravenous use only  Initiate administration as soon as possible after snake bite in patients who develop signs of envenomation (e.g. local injury, coagulation abnormality or systemic signs of envenomation)  Dose: (2.1) o Recommended initial dose is between 4 and 6 vials o Observe patient for up to one hour after the initial dose and give an additional 4-6 vial dose as needed to gain initial control of envenomation o After initial control is established, administer additional 2-vial doses every 6 hours for 18 hours (total of 3 doses)  Administration: (2.2) o Reconstitute each vial of CROFAB with 18 mL of 0.9% Sodium Chloride and mix by continuous manual inversion until no solid material is visible in the vial o Do not shake o Further dilute the entire dose with 0.9% Sodium Chloride to a total volume of 250 mL o Infuse each dose intravenously over at least 1 hour